(S)-Ro 32-0432 free base

Modify Date: 2024-01-12 08:55:07

(S)-Ro 32-0432 free base structure	Common Name	(S)-Ro 32-0432 free base
	CAS Number	151342-35-7	Molecular Weight	452.55
	Density	N/A	Boiling Point	711.9ºC at 760 mmHg
	Molecular Formula	C₂₈H₂₈N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	384.3ºC

Use of (S)-Ro 32-0432 free base

(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].

Name	bisindolylmaleimide X

Description	(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
References	[1]. A M Birchall, et al. Ro 32-0432, a Selective and Orally Active Inhibitor of Protein Kinase C Prevents T-cell Activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9. [2]. Thakur Gurjeet Singh, et al. Ro 32-0432 Attenuates Mecamylamine-Precipitated Nicotine Withdrawal Syndrome in Mice. Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):197-204.

Description

Related Catalog

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Inflammation/Immunology

Signaling Pathways >> TGF-beta/Smad >> PKC

References

[1]. A M Birchall, et al. Ro 32-0432, a Selective and Orally Active Inhibitor of Protein Kinase C Prevents T-cell Activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.

[2]. Thakur Gurjeet Singh, et al. Ro 32-0432 Attenuates Mecamylamine-Precipitated Nicotine Withdrawal Syndrome in Mice. Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):197-204.

Boiling Point	711.9ºC at 760 mmHg
Molecular Formula	C₂₈H₂₈N₄O₂
Molecular Weight	452.55
Flash Point	384.3ºC
Exact Mass	488.19800
PSA	59.27000
LogP	4.95500
Vapour Pressure	4.11E-20mmHg at 25°C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S)-Ro 32-0432 free base
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

(S)-Ro 32-0432 free base suppliers

(S)-Ro 32-0432 free base price

(S)-Ro 32-0432 free base

Use of (S)-Ro 32-0432 free base

Names

(S)-Ro 32-0432 free base Biological Activity

Chemical & Physical Properties