Estetrol

Modify Date: 2024-01-05 11:50:24

Estetrol Structure
Estetrol structure
Common Name Estetrol
CAS Number 15183-37-6 Molecular Weight 304.38100
Density 1.343 g/cm3 Boiling Point 491.9ºC at 760 mmHg
Molecular Formula C18H24O4 Melting Point N/A
MSDS Chinese USA Flash Point 231.7ºC

 Use of Estetrol


Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].

 Names

Name (8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
Synonym More Synonyms

 Estetrol Biological Activity

Description Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].
Related Catalog
Target

Estrogen receptor[1]

References

[1]. Valéra MC, et al. Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis. Mol Cell Endocrinol. 2018 Dec 5;477:132-139.

[2]. Montt-Guevara MM, et al. Estetrol Modulates Endothelial Nitric Oxide Synthesis in Human Endothelial Cells. Front Endocrinol (Lausanne). 2015 Jul 22;6:111.

 Chemical & Physical Properties

Density 1.343 g/cm3
Boiling Point 491.9ºC at 760 mmHg
Molecular Formula C18H24O4
Molecular Weight 304.38100
Flash Point 231.7ºC
Exact Mass 304.16700
PSA 80.92000
LogP 1.55080
Index of Refraction 1.65
Storage condition -20°C

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

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Estetrol Structure

Estetrol

CAS#:15183-37-6

Literature: Suzuki, Emako; Namba, Susumu; Kurihara, Hiroyuki; Goto, Junichi; Matsuki, Yasuhiko; Nambara, Toshio Steroids, 1995 , vol. 60, # 3 p. 277 - 284

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Estetrol Structure

Estetrol

CAS#:15183-37-6

Literature: EP2383279 A1, ;

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Estetrol Structure

Estetrol

CAS#:15183-37-6

Literature: EP2383279 A1, ;

~%

Estetrol Structure

Estetrol

CAS#:15183-37-6

Literature: EP2383279 A1, ;

~%

Estetrol Structure

Estetrol

CAS#:15183-37-6

Literature: EP2383279 A1, ;

~%

Estetrol Structure

Estetrol

CAS#:15183-37-6

Literature: Steroids, , vol. 60, # 3 p. 277 - 284

 Articles1

More Articles
Estetrol: a unique steroid in human pregnancy.

J. Steroid Biochem. Mol. Biol. 110(1-2) , 138-43, (2008)

Estetrol (E(4)) is an estrogenic steroid molecule synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta. Its function is presentl...

 Synonyms

ESTETROL
15|A-Hydroxyestriol
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