Afabicin
Modify Date: 2024-01-08 19:45:53
Afabicin structure
|
Common Name | Afabicin | ||
|---|---|---|---|---|
| CAS Number | 1518800-35-5 | Molecular Weight | 485.426 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 876.6±75.0 °C at 760 mmHg | |
| Molecular Formula | C23H24N3O7P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 483.9±37.1 °C | |
Use of AfabicinAfabicin is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. |
| Name | afabicin |
|---|---|
| Synonym | More Synonyms |
| Description | Afabicin is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. |
|---|---|
| Related Catalog | |
| Target |
FabI, Bacterial[1] |
| In Vitro | Afabicin (Debio1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively. Debio1452 also inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 876.6±75.0 °C at 760 mmHg |
| Molecular Formula | C23H24N3O7P |
| Molecular Weight | 485.426 |
| Flash Point | 483.9±37.1 °C |
| Exact Mass | 485.135193 |
| LogP | 0.87 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.667 |
| {6-[(1E)-3-{Methyl[(3-methyl-1-benzofuran-2-yl)methyl]amino}-3-oxo-1-propen-1-yl]-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl}methyl dihydrogen phosphate |
| 2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-[5,6,7,8-tetrahydro-7-oxo-8-[(phosphonooxy)methyl]-1,8-naphthyridin-3-yl]-, (2E)- |
| afabicin |
| DMM8663H2R |