Upidosin
Modify Date: 2024-01-10 06:10:01
Upidosin structure
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Common Name | Upidosin | ||
|---|---|---|---|---|
| CAS Number | 152735-23-4 | Molecular Weight | 511.61100 | |
| Density | 1.208g/cm3 | Boiling Point | 688.9ºC at 760 mmHg | |
| Molecular Formula | C31H33N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 370.4ºC | |
Use of UpidosinUpidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction[1]. |
| Name | N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-3-methyl-4-oxo-2-phenylchromene-8-carboxamide |
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| Synonym | More Synonyms |
| Description | Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction[1]. |
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| Related Catalog | |
| In Vitro | Upidosin is one of the most potent compounds action on the prostate with comparing the apparent pKB values, but its potency is slightly lower than that of tamsulosin and is higher than the potencies of prazosin, terazosin and 5-methylurapidil[2]. Upidosin shows binding affinities to cloned humanα1A, humanα1B, humanα1D adrenoceptors with pKi value of 9.0, 7.5 and 8.6, respectively[3]. |
| In Vivo | Upidosin shows greater selectivity than any other α-1 AR antagonist terazosin and tamsulosin in the anesthetized dog[1]. Upidosin (1-300 μg/kg; i.v.) is a more potent antagonist of phenylephrine mediated increases in prostatic pressure with a pA2 value of 8.74 compared to blood pressure with a pA2 value of 7.51[3]. |
| References |
| Density | 1.208g/cm3 |
|---|---|
| Boiling Point | 688.9ºC at 760 mmHg |
| Molecular Formula | C31H33N3O4 |
| Molecular Weight | 511.61100 |
| Flash Point | 370.4ºC |
| Exact Mass | 511.24700 |
| PSA | 78.51000 |
| LogP | 5.29680 |
| Vapour Pressure | 7.91E-19mmHg at 25°C |
| Index of Refraction | 1.608 |
| Rec 15-2739 |
| UNII-TXG28R7G4Y |
| UPIDOSIN |
| 4H-1-Benzopyran-8-carboxamide,N-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]-3-methyl-4-oxo-2-phenyl |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Upidosin
- Price: Negotiable
- Purity: 99.26%
- Delivery: 10 Day
- Contact: Tom
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: Upidosin
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥780/5 mg
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