NE 10790
Modify Date: 2024-01-11 21:01:58
NE 10790 structure
|
Common Name | NE 10790 | ||
|---|---|---|---|---|
| CAS Number | 152831-36-2 | Molecular Weight | 247.14200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H10NO6P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NE 10790NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. |
| Name | 2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. |
|---|---|
| Related Catalog | |
| Target |
FPP synthase[1]. |
| In Vitro | NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1]. |
| References |
| Molecular Formula | C8H10NO6P |
|---|---|
| Molecular Weight | 247.14200 |
| Exact Mass | 247.02500 |
| PSA | 137.76000 |
| Storage condition | 2-8℃ |
| 3-PEHPC |
| 3-(3-pyridyl)-2-hydroxy-2-phosphonopropanoic acid |
| NE-10790 |
| 2-hydroxy-2-phosphono-3-pyridin-3-ylpropanoic acid |
| 2-hydroxy-2-phosphono-3-(3-pyridyl)propionic acid |