Nolatrexed dihydrochloride
Modify Date: 2024-01-05 15:45:30
Nolatrexed dihydrochloride structure
|
Common Name | Nolatrexed dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 152946-68-4 | Molecular Weight | 357.258 | |
| Density | N/A | Boiling Point | 493.6ºCat 760 mmHg | |
| Molecular Formula | C14H14Cl2N4OS | Melting Point | 301-302ºC | |
| MSDS | N/A | Flash Point | 252.3ºC | |
Use of Nolatrexed dihydrochlorideNolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2]. |
| Name | 2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one,dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 11 nM (Human Thymidylate Synthase)[1] |
| References |
| Boiling Point | 493.6ºCat 760 mmHg |
|---|---|
| Melting Point | 301-302ºC |
| Molecular Formula | C14H14Cl2N4OS |
| Molecular Weight | 357.258 |
| Flash Point | 252.3ºC |
| Exact Mass | 356.026550 |
| PSA | 109.96000 |
| LogP | 4.54510 |
| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Hygroscopic |
| 2-Amino-6-methyl-5-(4-pyridinylsulfanyl)-4(1H)-quinazolinone dihydrochloride |
| Thymitaq |
| 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(3H)-one dihydrochloride |
| MFCD00917041 |
| 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2) |
| Nolatrexed dihydrochloride |
| AG 337 |