5-(DIMETHYLAMINO)-N-(3,4-DIMETHYL-5-ISOXAZOLYL)-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
Modify Date: 2024-03-05 09:10:30
5-(DIMETHYLAMINO)-N-(3,4-DIMETHYL-5-ISOXAZOLYL)-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE structure
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Common Name | 5-(DIMETHYLAMINO)-N-(3,4-DIMETHYL-5-ISOXAZOLYL)-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE | ||
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| CAS Number | 153042-42-3 | Molecular Weight | 345.42 | |
| Density | 1.332g/cm3 | Boiling Point | 524.5ºC at 760mmHg | |
| Molecular Formula | C17H19N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 271ºC | |
Use of 5-(DIMETHYLAMINO)-N-(3,4-DIMETHYL-5-ISOXAZOLYL)-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDEBMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1]. |
| Name | 5-(dimethylamino)-N-(3,4-dimethyl-1,2-oxazol-5-yl)naphthalene-1-sulfonamide |
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| Synonym | More Synonyms |
| Description | BMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1]. |
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| Related Catalog | |
| Target |
ETA:0.15 μM (IC50) ETA:0.055 μM (Ki) |
| References |
| Density | 1.332g/cm3 |
|---|---|
| Boiling Point | 524.5ºC at 760mmHg |
| Molecular Formula | C17H19N3O3S |
| Molecular Weight | 345.42 |
| Flash Point | 271ºC |
| Exact Mass | 345.11500 |
| PSA | 83.82000 |
| LogP | 4.46520 |
| Vapour Pressure | 4.3E-11mmHg at 25°C |
| Index of Refraction | 1.646 |
| Tocris-1441 |
| 5-Ddins |