AF38469
Modify Date: 2024-01-21 20:28:35
AF38469 structure
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Common Name | AF38469 | ||
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| CAS Number | 1531634-31-7 | Molecular Weight | 324.25500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H11F3N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AF38469AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. |
| Name | af38469 |
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| Synonym | More Synonyms |
| Description | AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. |
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| Related Catalog | |
| Target |
IC50:330 nM (Sortilin)[1] |
| In Vitro | AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of this protein[1]. |
| References |
| Molecular Formula | C15H11F3N2O3 |
|---|---|
| Molecular Weight | 324.25500 |
| Exact Mass | 324.07200 |
| PSA | 79.29000 |
| LogP | 3.43230 |
| Storage condition | 2-8℃ |
| 2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid |