Pleconaril
Modify Date: 2024-01-02 18:31:21
Pleconaril structure
|
Common Name | Pleconaril | ||
|---|---|---|---|---|
| CAS Number | 153168-05-9 | Molecular Weight | 381.349 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 481.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H18F3N3O3 | Melting Point | 61-62° | |
| MSDS | Chinese USA | Flash Point | 244.8±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of PleconarilPleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM.Target: enterovirusPleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure,preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections. |
| Name | 3-[3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole |
|---|---|
| Synonym | More Synonyms |
| Description | Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM.Target: enterovirusPleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure,preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 481.2±55.0 °C at 760 mmHg |
| Melting Point | 61-62° |
| Molecular Formula | C18H18F3N3O3 |
| Molecular Weight | 381.349 |
| Flash Point | 244.8±31.5 °C |
| Exact Mass | 381.130035 |
| PSA | 74.18000 |
| LogP | 5.77 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.509 |
| Storage condition | room temp |
| Water Solubility | DMSO: ≥10mg/mL (warmed) |
|
Molecular mechanism of a specific capsid binder resistance caused by mutations outside the binding pocket.
Antiviral Res. 123 , 138-45, (2015) Enteroviruses cause various acute and chronic diseases. The most promising therapeutics for these infections are capsid-binding molecules. These can act against a broad spectrum of enteroviruses, but ... |
|
|
Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection.
J. Pharm. Biomed. Anal. 13(9) , 1189-93, (1995)
|
| Pleconaril |
| Picovir |
| Pleconarilis |