Zinc protoporphyrin

Modify Date: 2024-01-02 20:22:06

Zinc protoporphyrin Structure
Zinc protoporphyrin structure
Common Name Zinc protoporphyrin
CAS Number 15442-64-5 Molecular Weight 626.051
Density N/A Boiling Point 1128.5ºC at 760mmHg
Molecular Formula C34H32N4O4Zn Melting Point N/A
MSDS Chinese USA Flash Point 636.3ºC

 Use of Zinc protoporphyrin


Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2].

 Names

Name zinc protoporphyrin
Synonym More Synonyms

 Zinc protoporphyrin Biological Activity

Description Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2].
Related Catalog
References

[1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4).

[2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229.

 Chemical & Physical Properties

Boiling Point 1128.5ºC at 760mmHg
Molecular Formula C34H32N4O4Zn
Molecular Weight 626.051
Flash Point 636.3ºC
Exact Mass 624.171509
PSA 109.18000
LogP 3.60970
Vapour Pressure 0mmHg at 25°C

 MSDS


Section 1: Product Identification
Chemical Name:Zinc protoporphyrin
CAS Registry Number:15442-64-5
Formula:(C34H32N4O4)Zn
EINECS Number:239-455-7
Chemical Family:metal porphine (porphyrin) complex
Synonym:protoporphoryn zinc chelate

Section 2: Composition and Information on Ingredients
IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL)
Title Compound15442-64-5100%no datano data

Section 3: Hazards Identification
Emergency Overview:Dust may be irritating to skin, eyes and mucous membranes. May be harmful if swallowed.
Primary Routes of Exposure:Ingestion, inhalation
Eye Contact:May cause slight to mild irritation of the eyes.
Skin Contact:May cause slight to mild irritation of the skin.
Inhalation:Some zinc containing dusts irritate the respiratory system and cause metallic taste, dry throat, and chills.
Ingestion:If solubilized, Zinc compounds give a harsh metallic taste and may cause nausea and vomiting.
Acute Health Affects:May be irritating to skin, eyes and respiratory tract. Inhalation may cause chills and nausea.
No serious long-term chronic effects associated with zinc compounds. Prolonged inhalation may cause
Chronic Health Affects:
laryngitis. Prolonged ingestion may cause constipation.
NTP:No
IARC:No
OSHA:No

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

SECTION 5: Fire Fighting Measures
Flash Point:not applicable
Autoignition Temperature:none
Explosion Limits:none
Extinguishing Medium:carbon dioxide, foam or dry powder
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self- contained breathing apparatus and full protective clothing.
Hazardous Combustion andIf involved in a fire this material may emit toxic and corrosive fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

SECTION 6: Accidental Release Measures
Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and
Spill and Leak Procedures:
swept up.

SECTION 7: Handling and Storage
Handling and Storage:Store in a cool, dry place in a tightly sealed container.

SECTION 8: Exposure Controls and Personal Protection
Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection:Wear protective clothing and gloves.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection:No additional protection required.

SECTION 9: Physical and Chemical Properties
Color and Form:purple xtl.
Molecular Weight:626.03
Melting Point:no data
Boiling Point:no data
Vapor Pressure:no data
Specific Gravity:no data
Odor:none
Solubility in Water:Insoluble

SECTION 10: Stability and Reactivity
Stability:air and moisture stable
Hazardous Polymerization:no hazardous polymerization
Conditions to Avoid:none
Incompatibility:Oxidizing agents
Decomposition Products:zinc oxide, nitrogen oxides, carbon monoxide, carbon dioxide and organic fumes.

SECTION 11: Toxicological Information
RTECS Data:No information available in the RTECS files.
Carcinogenic Effects:No data
Mutagenic Effects:No data
Tetratogenic Effects:No data

SECTION 12: Ecological Information
Ecological Information:Avoid release to the environment. Very toxic to aquatic organisms.

SECTION 13: Disposal Considerations
This material and its container must be disposed of as hazardous waste according to local, state and federal
Disposal:
regulations.

SECTION 14: Transportation
Shipping Name (CFR):Non-hazardous
Hazard Class (CFR):NA
Additional Hazard Class (CFR):NA
Packaging Group (CFR):NA
UN ID Number (CFR):NA
Shipping Name (IATA):Non-hazardous
Hazard Class (IATA):NA
Additional Hazard Class (IATA):NA
Packaging Group (IATA):NA
UN ID Number (IATA):NA

SECTION 15: Regulatory Information
TSCA:Listed in the TSCA inventory.
SARA (Title 313):Title compound: See category N982 for reporting.
Second Ingredient:None


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  1

DownStream  0

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 Synonyms

Protoporphyrin IX zinc(II)
EINECS 239-455-7
21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethenyl-3,7,12,17-tetramethyl-, zinc salt (1:1)
MFCD00011612
[3,3'-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]zinc
zinc 2,18-bis(2-carboxyethyl)-7,12-diethenyl-3,8,13,17-tetramethylporphine-21,23-diide
Zinc 2,18-bis(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinylporphine-21,23-diide
PROTOPORPHYRINATO ZINC
zinc,3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
Zinc Protoporphyrin
Zinc, [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]-
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