Plerixafor 8HCl (AMD3100 8HCl)

Modify Date: 2024-01-02 10:32:42

Plerixafor 8HCl (AMD3100 8HCl) structure	Common Name	Plerixafor 8HCl (AMD3100 8HCl)
	CAS Number	155148-31-5	Molecular Weight	830.500
	Density	0.962g/cm3	Boiling Point	657.5ºC at 760mmHg
	Molecular Formula	C₂₈H₆₂Cl₈N₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	361.8ºC

Use of Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor octahydrochloride is a selective CXCR4 antagonist with an IC50 of 44 nM.

Name	AMD3100 octahydrochloride hydrate
Synonym	More Synonyms

Description	Plerixafor octahydrochloride is a selective CXCR4 antagonist with an IC50 of 44 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Inflammation/Immunology
Target	125I-CXCL12-CXCR4:44 nM (IC50)
In Vitro	The CXCR4 inhibitor Plerixafor (AMD3100) is a potent inhibitor of CXCL12-mediated chemotaxis (IC50, 5.7 nM) with a potency slightly better than its affinity for CXCR4. Treating the cells with CCX771 or CXCL11 has no effect on CXCL12-mediated MOLT-4 or U937 TEM. In contrast, 10 μM Plerixafor inhibits CXCL12-mediated TEM in both cells lines[1]. Plerixafor (10 μM)-treated cells show a moderate reduction in cell proliferation compared to CXCL12-stimulated cells, which do not reach statistical significance[2].
In Vivo	Plerixafor (2 mg/kg) administration to UUO mice exacerbates renal interstitial T cell infiltration, resulting in increased production of the pro-inflammatory cytokines IL-6 and IFN-γ and decreased expression of the anti-inflammatory cytokine IL-10[3]. Both perivascular and interstitial fibrosis are significantly reduced by the CXCR4 antagonist, Plerixafor (AMD3100) at 8 weeks[4]. LD50, mouse, SC: 16.3 mg/kg; LD50, rat, SC: >50 mg/kg; LD50, mouse and rat, IV injection: 5.2 mg/kg.
Cell Assay	U87MG cells are seeded in 96-well plates at the density of 6×103 cells in 200 μL/well and treated with CXCL12, Plerixafor or with peptide R, as described in the previous “Treatments” section. MTT (5 μg/mL) is added at each time point (24, 48, 72 h) during the final 2 h of treatment. After removing cell medium, 100 μL DMSO are added and optical densities measured at 595 nm with a LT-4000MS Microplate Reader. Measurements are made in triplicates from three independent experiments[2].
Animal Admin	Mice[3] Male C57bl/6 mice (6-7 weeks old, weighing 20 g) are used. The animals are acclimated to the housing environment, which is SPF and had a temperature of 22°C and a 12h/12h light/dark cycle for a week. Then, they are randomly divided into following experimental groups, with 8 mice in each group: normal (no specific intervention), UUO+AMD3100 (mice received UUO surgery and 2 mg/kg AMD3100), and UUO+PBS (mice received UUO surgery and the same volume of PBS). AMD3100 and PBS are administered via intraperitoneal injection every day until sacrifice. Rats[4] The CXCR4 antagonist, AMD3100 dissolved in H2O, is delivered in the type 2 diabetic sand rat model at a dose of 6 mg/kg per day for 8 weeks. In complementary studies, the effect of CXCR4 antagonism (AMD3100 6mg/kg/d) on regulatory T cell numbers is examined. For these studies, AMD3100 or vehicle is delivered via minipump for a period of one week.
References	[1]. Zabel BA, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183(5):3204-11. [2]. Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55. [3]. Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926. [4]. Chu PY, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10(7):e0133616.

Density	0.962g/cm3
Boiling Point	657.5ºC at 760mmHg
Molecular Formula	C₂₈H₆₂Cl₈N₈
Molecular Weight	830.500
Flash Point	361.8ºC
Exact Mass	826.281677
PSA	78.66000
LogP	8.68040
Appearance of Characters	solid
Vapour Pressure	2.85E-33mmHg at 25°C
Storage condition	−20°C
Water Solubility	H2O: ≥10 mg/mL, clear

Safety Phrases	22-24/25
WGK Germany	3

Bicyclam

Plerixafor 8HCl

1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride, hydrate (1:8:2)

AMD 3100 octahydrochloride

1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane)octahydrochloride

1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride dihydrate

1,4,8,11-Tetraazacyclotetradecane (1,1'-[1,4-phenylenebis(methylene)]bis-

Plerixafor

Plerixafor octahydrochloride

AMD3100 8HCl

Plerixafor (octahydrochloride)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Plerixafor 8HCl (AMD3100 8HCl)
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Plerixafor 8HCl (AMD3100 8HCl)
Price: ￥488.0/25mg ￥1438.0/50mg
Purity: 99.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Plerixafor octahydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Plerixafor octahydrochloride
Price: $250.0/100mg $450.0/250mg $1000.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: AMD 3100; PLERIXAFOR
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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