Gallocyanine

Modify Date: 2024-01-03 19:11:43

Gallocyanine structure	Common Name	Gallocyanine
	CAS Number	1562-85-2	Molecular Weight	336.727
	Density	1.3979 (rough estimate)	Boiling Point	497ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₃ClN₂O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	254.4ºC
	Symbol	GHS07	Signal Word	Warning

Use of Gallocyanine

Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Its association with LRP6 is weak (IC50 of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies[1].

Name	Gallocyanine
Synonym	More Synonyms

Description	Gallocyanine chloride, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Its association with LRP6 is weak (IC50 of about 3 μM in the inhibition of DKK1 binding). Gallocyanine dye acts as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Neurological Disease
References	[1]. Spyros Mpousis, et al. Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies. Eur J Med Chem. 2016 Jan 27;108:28-38.

Density	1.3979 (rough estimate)
Boiling Point	497ºC at 760 mmHg
Molecular Formula	C₁₅H₁₃ClN₂O₅
Molecular Weight	336.727
Flash Point	254.4ºC
Exact Mass	336.051300
PSA	107.03000
Index of Refraction	1.6500 (estimate)

Gallocyanine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP7692000

CHEMICAL NAME :: Phenoxazin-5-ium, 1-carboxy-7-(dimethylamino)-3,4-dihydroxy-, chloride

CAS REGISTRY NUMBER :: 1562-85-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H13-N2-O5.Cl

MOLECULAR WEIGHT :: 336.75

WISWESSER LINE NOTATION :: T C666 BN IOJ DVQ FQ GQ LN1&1 &G &12/32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 1000 ppm

REFERENCE :: AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year: 87,295,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3052 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 131 (estimated) No. of Female Employees: 81 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SP7692000
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

[Determination of the relative RNA-content of liver cell nuclei with gallocyanin-chromealum-staining (author's transl)].

Acta Histochem. 69(2) , 307-13, (1981)

The relative RNA-content of liver cell nuclei from histological slides of rat liver was determined by automatical microscope picture analysis. The slides were stained with Gallocyanin-Chromealum. Exti...

Remarks on the usefulness of toluidine blue staining for RNA cytophotometry in plastic embedded tissues.

Cell Mol. Biol. 45(4) , 379-82, (1999)

The study demonstrates the usefulness of water-soluble plastic resins for the cytological quantification of RNA contents after toluidine blue staining. In this way shrinkage artefacts in delicate tiss...

The involvement of nucleosomes in Giemsa staining of chromosomes. A new hypothesis on the banding mechanism.

Histochemistry 82(4) , 363-76, (1985)

A new hypothesis is proposed on the involvement of nucleosomes in Giemsa banding of chromosomes. Giemsa staining as well as the concomitant swelling can be explained as an insertion of the triple char...

EINECS 216-345-7

C.I. Mordant Blue 10 (8CI)

MFCD00011926

1-Carboxy-7-(dimethylamino)-3,4-dihydroxyphenoxazin-5-ium chloride

7-Dimethylamino-4-hydroxy-3-oxo-phenoxazine-1-carboxylic acid

Phenoxazinium, 1-carboxy-7-(dimethylamino)-3,4-dihydroxy-, chloride (1:1)

Gallocyanine

Phenoxazin-5-ium, 1-carboxy-7- (dimethylamino)-3,4-dihydroxy-, chloride

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Gallocyanine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gallocyanine
Price: ￥68.0/500mg ￥98.0/1g ￥328.0/10g
Purity: 90.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Gallocyanine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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