SM-1295
Modify Date: 2024-03-06 12:01:35
SM-1295 structure
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Common Name | SM-1295 | ||
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| CAS Number | 1562375-46-5 | Molecular Weight | 598.542 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H36BrN5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SM-1295SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP; potently inhibits cell growth in the MDA-MB-231 and SK-OV-3 cancer cell lines and induces apoptosis at low nanomolar concentrations; efficiently induces degradation of cIAP1 protein in cancer cells, as well as cleavage of PARP, caspase-8, and caspase-3; induces cell death in a TNFα-dependent manner in both MDA-MB-231 and SK-OV-3 cancer cell lines. |
| Name | SM-1295 |
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| Description | SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP; potently inhibits cell growth in the MDA-MB-231 and SK-OV-3 cancer cell lines and induces apoptosis at low nanomolar concentrations; efficiently induces degradation of cIAP1 protein in cancer cells, as well as cleavage of PARP, caspase-8, and caspase-3; induces cell death in a TNFα-dependent manner in both MDA-MB-231 and SK-OV-3 cancer cell lines. |
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| References | References 1. Sun H, et al. ACS Chem Biol. 2014 Apr 18;9(4):994-1002. View Related Products by Target IAP |
| Molecular Formula | C29H36BrN5O4 |
|---|---|
| Molecular Weight | 598.542 |