380623-76-7

380623-76-7 structure

Name: SM 7368
Chemical Name: 3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
CAS Number: 380623-76-7
Molecular Formula: C₁₀H₅ClN₄O₅S
Molecular Weight: 328.68900
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-06-26 15:38:15
Modify Date: 2024-01-14 12:10:21
SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].

Name	3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
Synonyms	NF-kappaB Activation Inhibitor III SM-7368 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide Benzamide,3-chloro-4-nitro-N-(5-nitro-2-thiazolyl) 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide,SM 7368

Description	SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	NF-κB MMP-9 p38 MAP kinase
In Vitro	SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line[2]. SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation[2]. Western Blot Analysis[2] Cell Line: HT1080 human fibrosarcoma cells Concentration: 0, 1, 5, 10, 15, 20, and 25 μM Incubation Time: 24 hours Result: Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.
References	[1]. Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54(10):1458-67. [2]. Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22.

Molecular Formula	C₁₀H₅ClN₄O₅S
Molecular Weight	328.68900
Exact Mass	327.96700
PSA	165.36000
LogP	4.29560

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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