MART-1 (26-35) (human) trifluoroacetate salt

Modify Date: 2024-01-03 08:59:24

MART-1 (26-35) (human) trifluoroacetate salt Structure
MART-1 (26-35) (human) trifluoroacetate salt structure
Common Name MART-1 (26-35) (human) trifluoroacetate salt
CAS Number 156251-01-3 Molecular Weight 943.096
Density 1.2±0.1 g/cm3 Boiling Point 1358.4±65.0 °C at 760 mmHg
Molecular Formula C42H74N10O14 Melting Point N/A
MSDS N/A Flash Point 775.3±34.3 °C

 Use of MART-1 (26-35) (human) trifluoroacetate salt


MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 protein.

 Names

Name Melan-A, MART 1 (26-35),EAAGIGILTV
Synonym More Synonyms

  Biological Activity

Description MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 protein.
Related Catalog
In Vitro MART-1 (Melan-A) gene is 18 kb long and comprises five exons. It is expressed in most melanoma tumor samples, and among normal cells, only in melanocytes[1]. In cancer immunotherapy, epitopes and variants derived from the MART-1/Melan-A protein are widely used as clinical vaccines. The epitopes spanning amino acid residues 26–35 and 27–35 from the MART-1/Melan-A protein, highly expressed in melanoma cells, provide a prime example of T cell recognition of multiple peptides and the use of peptide variants designed to elicit altered immunological responses[2].
References

[1]. Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42.

[2]. Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 1358.4±65.0 °C at 760 mmHg
Molecular Formula C42H74N10O14
Molecular Weight 943.096
Flash Point 775.3±34.3 °C
Exact Mass 942.538574
PSA 382.75000
LogP 1.19
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.527

 Synonyms

Melan-A,MART 1 (26-35)
ANTIGEN SK29-AA (26-35) (HUMAN)
L-α-Glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-valine
MART-1 (26-35) (HUMAN)
GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
ANTIGEN LB39-AA (26-35) (HUMAN)
MELAN-A PROTEIN (26-35) (HUMAN)
EAAGIGILTV
L-Valine, L-α-glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
MART-1 (26-35),human (3)
MELAN-A
MART 1 (26-35)
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