Chrysotoxine

Modify Date: 2024-07-19 00:19:04

Chrysotoxine structure	Common Name	Chrysotoxine
	CAS Number	156951-82-5	Molecular Weight	318.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Chrysotoxine

Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].

Name	4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol
Synonym	More Synonyms

Description	Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> PI3K/Akt/mTOR >> Akt
References	[1]. Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346. [2]. Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

References

[1]. Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346.

[2]. Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.