(S)-SNAP 5114
(S)-SNAP 5114 structure
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Common Name | (S)-SNAP 5114 | ||
|---|---|---|---|---|
| CAS Number | 157604-55-2 | Molecular Weight | 505.60 | |
| Density | 1.175g/cm3 | Boiling Point | 643.9ºC at 760mmHg | |
| Molecular Formula | C30H35NO6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 343.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of (S)-SNAP 5114(S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug[1][2]. |
| Name | (3S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | (S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 5 μM (hGAT-3), 21 μM (rGAT-2)[1]. |
| References |
| Density | 1.175g/cm3 |
|---|---|
| Boiling Point | 643.9ºC at 760mmHg |
| Molecular Formula | C30H35NO6 |
| Molecular Weight | 505.60 |
| Flash Point | 343.2ºC |
| Exact Mass | 505.24600 |
| PSA | 77.46000 |
| LogP | 4.75540 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.571 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
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GABA transporter heterogeneity: pharmacology and cellular localization.
Neurochem. Int. 29 , 335, (1996) gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent trans... |
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GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
Neuropharmacology 39 , 2399-2407, (2000) The present study examines the effect of tiagabine (a selective inhibitor of GABA transporter 1, GAT-1), SNAP-5114 (a semi-selective inhibitor of rat GAT-3/mouse GAT4) and NNC 05-2045 (a non-selective... |
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GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii.
PLoS Pathog. 8 , e1003051, (2012) During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes. Poised to respond to invading pathogens,... |
| HMS3268E15 |
| SNAP-5114 |
| Pseudo RACK1 |
| (S)-SNAP-5114 |