Montelukast

Modify Date: 2024-01-01 17:27:09

Montelukast structure	Common Name	Montelukast
	CAS Number	158966-92-8	Molecular Weight	586.183
	Density	1.3±0.1 g/cm3	Boiling Point	750.5±60.0 °C at 760 mmHg
	Molecular Formula	C₃₅H₃₆ClNO₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	407.7±32.9 °C

Use of Montelukast

Montelukast is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast can be used for the reseach of asthma and liver injury. Montelukast also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].

Name	montelukast
Synonym	More Synonyms

Description	Montelukast is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast can be used for the reseach of asthma and liver injury. Montelukast also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	CysLT1
In Vitro	Montelukast (5 μM; 1 h) inhibits APAP-induced cell damage[1].
In Vivo	Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice[1]. Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor[2]. Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice[2]. Animal Model: C57BL/6J mice (8-week-old; 22-25 g) are induced acute hepatic injury[1] Dosage: 3 mg/kg Administration: Oral gavage 1 h after saline or APAP administration Result: Decreased serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and alleviated liver damage.
References	[1]. Pu S, et, al. Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury. Front Pharmacol. 2019 Sep 18; 10:1070. [2]. William RHJ, et, al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med. 2002 Jan 1; 165(1): 108-16.

Density	1.3±0.1 g/cm3
Boiling Point	750.5±60.0 °C at 760 mmHg
Molecular Formula	C₃₅H₃₆ClNO₃S
Molecular Weight	586.183
Flash Point	407.7±32.9 °C
Exact Mass	585.210449
PSA	95.72000
LogP	7.80
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.678
Storage condition	2-8°C

Hazard Codes	Xi

Precursor 10
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CAS#:151767-02-1 Montelukast sodium CAS#:577953-88-9 Montelukast Dic...
DownStream 2
CAS#:577953-88-9 Montelukast Dic... CAS#:151767-02-1 Montelukast sodium