Etripamil

Modify Date: 2024-01-08 19:52:03

Etripamil Structure
Etripamil structure
Common Name Etripamil
CAS Number 1593673-23-4 Molecular Weight 452.59
Density 1.1±0.1 g/cm3 Boiling Point 593.8±50.0 °C at 760 mmHg
Molecular Formula C27H36N2O4 Melting Point N/A
MSDS N/A Flash Point 312.9±30.1 °C

 Use of Etripamil


Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist with a rapid onset of action designed for intranasal administration, used to treat Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells[1][2].

 Names

Name Etripamil
Synonym More Synonyms

 Etripamil Biological Activity

Description Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist with a rapid onset of action designed for intranasal administration, used to treat Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells[1][2].
Related Catalog
Target

L-type calcium channel

References

[1]. Stambler BS, et al. Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm. J Am Coll Cardiol. 2018 Jul 31;72(5):489-497.

[2]. Milestone Pharmaceuticals Announces USAN Approval of Generic Name “Etripamil” for its Phase 2 Clinical Development Product for the Treatment of Paroxysmal Supraventricular Tachycardia.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 593.8±50.0 °C at 760 mmHg
Molecular Formula C27H36N2O4
Molecular Weight 452.59
Flash Point 312.9±30.1 °C
Exact Mass 452.267517
LogP 4.14
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.534

 Synonyms

MSP-2017
UNII:S82A18Y42P
(-)-MSP-2017
Methyl 3-(2-{[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl](methyl)amino}ethyl)benzoate
Benzoic acid, 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]-, methyl ester
Etripamil