BMS-466442
Modify Date: 2024-01-10 18:18:43
BMS-466442 structure
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Common Name | BMS-466442 | ||
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| CAS Number | 1598424-76-0 | Molecular Weight | 538.594 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 827.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C31H30N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 454.1±34.3 °C | |
Use of BMS-466442BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2]. |
| Name | Methyl 1-benzyl-N-{[6-(benzyloxy)-5-methoxy-1H-indol-2-yl]carbonyl}-L-histidinate |
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| Synonym | More Synonyms |
| Description | BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2]. |
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| Related Catalog | |
| Target |
IC50: 1 nM (asc-1), 420 nM (dopamine transporter), 6.1 μM (Adrenergic α1D receptor), ≥10 μM (LAT-2), ≥10 μM (ASCT-2)[1] |
| In Vitro | BMS-466442 dose-dependently inhibits asc-1 activity in human asc-1 expressing cells and primary cultures with IC50 values of 36.8 ± 11.6 nM and 19.7 ± 6.7 nM, respectively[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 827.3±65.0 °C at 760 mmHg |
| Molecular Formula | C31H30N4O5 |
| Molecular Weight | 538.594 |
| Flash Point | 454.1±34.3 °C |
| Exact Mass | 538.221619 |
| LogP | 4.33 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.630 |
| L-Histidine, N-[[5-methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-, methyl ester |
| Methyl 1-benzyl-N-{[6-(benzyloxy)-5-methoxy-1H-indol-2-yl]carbonyl}-L-histidinate |