HA-15

Modify Date: 2024-01-03 16:00:11

HA-15 Structure
HA-15 structure
Common Name HA-15
CAS Number 1609402-14-3 Molecular Weight 466.576
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C23H22N4O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HA-15


HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1]In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cellseither sensitive or resistant to BRAF inhibitors. [1]

 Names

Name HA15
Synonym More Synonyms

 HA-15 Biological Activity

Description HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1]In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cellseither sensitive or resistant to BRAF inhibitors. [1]
Related Catalog
References

[1]. Cerezo M et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29(6):805-19.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C23H22N4O3S2
Molecular Weight 466.576
Exact Mass 466.113342
LogP 4.56
Index of Refraction 1.701
Storage condition -20℃

 Synonyms

N-{4-[3-({[5-(Dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]-1,3-thiazol-2-yl}acetamide
Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
HA15
HA-15