(E)-GABAB receptor antagonist 1
Modify Date: 2024-01-23 15:31:35
(E)-GABAB receptor antagonist 1 structure
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Common Name | (E)-GABAB receptor antagonist 1 | ||
|---|---|---|---|---|
| CAS Number | 1611483-29-4 | Molecular Weight | 304.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H24O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (E)-GABAB receptor antagonist 1(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM[1]. |
| Name | (E)-GABAB receptor antagonist 1 |
|---|
| Description | (E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM[1]. |
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| Target |
GABAB receptor[1] |
| In Vitro | (E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50[1]. |
| References |
| Molecular Formula | C18H24O4 |
|---|---|
| Molecular Weight | 304.38 |