444724-92-9

444724-92-9 structure

Name: Dopamine D4 receptor antagonist-1
Chemical Name: Dopamine D4 receptor antagonist-1
CAS Number: 444724-92-9
Molecular Formula: C₁₈H₁₉ClN₄
Molecular Weight: 326.82
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2022-11-22 07:24:13
Modify Date: 2024-04-03 16:08:42
Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1].

Name	Dopamine D4 receptor antagonist-1

Description	Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vivo	Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus)[1]. Animal Model: Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT)[1]. Dosage: 10 mg/kg Administration: Intraperitoneal injection, single. Result: Increased DOPA accumulation in the hippocampus with no effect observed in the striatum.
References	[1]. Pugsley TA, et al. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26.

Molecular Formula	C₁₈H₁₉ClN₄
Molecular Weight	326.82