7-Hydroxycoumarinyl arachidonate

Modify Date: 2024-01-05 09:22:14

7-Hydroxycoumarinyl arachidonate structure	Common Name	7-Hydroxycoumarinyl arachidonate
	CAS Number	161180-11-6	Molecular Weight	448.594
	Density	1.1±0.1 g/cm3	Boiling Point	584.7±50.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₆O₄	Melting Point	N/A
	MSDS	USA	Flash Point	289.4±28.5 °C

Use of 7-Hydroxycoumarinyl arachidonate

7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3].

Name	(2-oxochromen-7-yl) icosa-5,8,11,14-tetraenoate
Synonym	More Synonyms

Description	7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
In Vitro	MAGL catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonate (7-HCA) into arachidonic acid (AA) and 7-HC. Release of 7-HC, which is fluorescent, is monitored over time with excitation (Ex) at 355 nm and emission (Em) at 460 nm[1].
References	[1]. Yuren Wang, et al. A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening. Assay Drug Dev Technol. 2008 Jun;6(3):387-93. [2]. Z Huang, et al. A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2. Anal Biochem. 1994 Oct;222(1):110-5. [3]. R T Pickard, et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem. 1996 Aug 9;271(32):19225-31.

Density	1.1±0.1 g/cm3
Boiling Point	584.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₆O₄
Molecular Weight	448.594
Flash Point	289.4±28.5 °C
Exact Mass	448.261353
PSA	56.51000
LogP	8.02
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.545

Hazard Codes	F: Flammable;Xi: Irritant;
Risk Phrases	R11
Safety Phrases	7-16-26-36
RIDADR	UN 1170 3/PG 2

7-HC-arachidonate

Umbelliferyl Arachidonate

2-Oxo-2H-chromen-7-yl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate

5,8,11,14-Eicosatetraenoic acid, 2-oxo-2H-1-benzopyran-7-yl ester, (5Z,8Z,11Z,14Z)-

DC Chemicals Limited
China
Product Name: 7-Hydroxycoumarinyl arachidonate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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7-Hydroxycoumarinyl arachidonate

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