PAO-Nap

Modify Date: 2024-01-02 16:11:12

PAO-Nap Structure
PAO-Nap structure
Common Name PAO-Nap
CAS Number 1613402-20-2 Molecular Weight 509.39
Density N/A Boiling Point N/A
Molecular Formula C24H24AsN3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PAO-Nap


PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].

 Names

Name PAO-Nap

 PAO-Nap Biological Activity

Description PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].
Related Catalog
In Vitro PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].
References

[1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.

 Chemical & Physical Properties

Molecular Formula C24H24AsN3O5
Molecular Weight 509.39
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