GUT-70
Modify Date: 2024-02-09 16:25:12
GUT-70 structure
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Common Name | GUT-70 | ||
|---|---|---|---|---|
| CAS Number | 161633-75-6 | Molecular Weight | 382.456 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H26O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GUT-70GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. |
| Name | GUT-70 |
|---|
| Description | GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. |
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| References | References 1. Kimura S, et al. Int J Cancer. 2005 Jan 1;113(1):158-65. 2. Jin L, et al. Br J Cancer. 2011 Jan 4;104(1):91-100. 3. Kudo E, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9. View Related Products by Target Apoptosis Inducer |
| Molecular Formula | C23H26O5 |
|---|---|
| Molecular Weight | 382.456 |