1031367-64-2

1031367-64-2 structure

Name: MC-70
Chemical Name: MC70
CAS Number: 1031367-64-2
Molecular Formula: C₂₄H₂₅NO₃
Molecular Weight: 375.46
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P-glycoprotein
Create Date: 2018-07-03 06:28:21
Modify Date: 2024-01-02 12:51:02
MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].

Name	MC70
Synonyms	4'-[(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)methyl]-4-biphenylol 4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol; MC70 4'-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]biphenyl-4-ol [1,1'-Biphenyl]-4-ol, 4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl]-

Description	MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Target	EC50: 0.69 µM (P-glycoprotein)[1]
References	[1]. Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jul 28;59(14):6729-38. [2]. Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670(1):74-84.