UCB9608

Modify Date: 2024-01-28 21:39:07

UCB9608 Structure
UCB9608 structure
Common Name UCB9608
CAS Number 1616413-96-7 Molecular Weight 410.47
Density N/A Boiling Point N/A
Molecular Formula C20H26N8O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of UCB9608


UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1].

 Names

Name UCB9608

 UCB9608 Biological Activity

Description UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1].
Related Catalog
In Vitro UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM. UCB9608 is selective for PI4KIIIβ over PI3KC2 α, β, and γ lipid kinases[1]. UCB9608 inhibits human mixed lymphocyte reaction, the IC50 is 37 nM[1].
References

[1]. Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem. 2018 Aug 9;61(15):6705-6723.

 Chemical & Physical Properties

Molecular Formula C20H26N8O2
Molecular Weight 410.47
Storage condition 2-8℃