L-371257

Modify Date: 2024-01-11 23:04:59

L-371257 structure	Common Name	L-371257
	CAS Number	162042-44-6	Molecular Weight	507.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₃N₃O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of L-371257

L-371,257 is an orally bioavailable, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM)[1][2].

Name	1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one
Synonym	More Synonyms

Description	L-371,257 is an orally bioavailable, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM)[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor
Target	Ki: 19 nM (oxytocin receptor), 3.7 nM (vasopressin V1a receptor)[2]
References	[1]. Williams PD, et al. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem. 1995 Nov 10;38(23):4634-6. [2]. Tunstall BJ, et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol. 2019 Apr 16;17(4):e2006421.

Molecular Formula	C₂₈H₃₃N₃O₆
Molecular Weight	507.58
Exact Mass	507.23700
PSA	88.62000
LogP	3.78710
Storage condition	-20°C

l-371,257

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L-371257
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: L-371257
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: L-371257
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: ￥3900/5 mg

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L-371257

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