VU0483605
Modify Date: 2024-01-05 12:35:43
VU0483605 structure
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Common Name | VU0483605 | ||
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| CAS Number | 1623101-11-0 | Molecular Weight | 446.67 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H10Cl3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU0483605VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively[1]. |
| Name | 2-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)phenyl]nicotinamide |
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| Synonym | More Synonyms |
| Description | VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively[1]. |
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| Related Catalog | |
| Target |
Human mGluR1:390 nM (EC50) rat mGluR1:356 nM (EC50) Human mGlu4:>10 μM (EC50) |
| In Vitro | VU0483605 proves superior with excellent mGlu1 PAM activity at both human (EC50 = 390 nM) and rat (EC50 = 356 nM, pEC50 = 6.45 ± 0.11, 113 ± 5% Glu Max) and no activity as an mGlu4 PAM (EC50 >10 μM)[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H10Cl3N3O3 |
| Molecular Weight | 446.67 |
| Exact Mass | 444.978760 |
| LogP | 3.87 |
| Index of Refraction | 1.728 |
| Storage condition | 2-8°C |
| vu0483605 |
| 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide |
| 2-Pyridinecarboxamide, 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]- |