EMT inhibitor-1

Modify Date: 2024-01-02 21:46:04

EMT inhibitor-1 Structure
EMT inhibitor-1 structure
Common Name EMT inhibitor-1
CAS Number 1638526-21-2 Molecular Weight 319.21
Density N/A Boiling Point N/A
Molecular Formula C12H12Cl2N2O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EMT inhibitor-1


EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

 Names

Name EMT inhibitor-1

 EMT inhibitor-1 Biological Activity

Description EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
Related Catalog
Target

Hippo, TGF-β, Wnt[1].

In Vitro EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1].
In Vivo EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].
References

[1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.

 Chemical & Physical Properties

Molecular Formula C12H12Cl2N2O2S
Molecular Weight 319.21
Storage condition 2-8℃
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