LY 311727
Modify Date: 2024-01-04 09:17:15
LY 311727 structure
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Common Name | LY 311727 | ||
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| CAS Number | 164083-84-5 | Molecular Weight | 430.43400 | |
| Density | 1.32g/cm3 | Boiling Point | 758.2ºC at 760mmHg | |
| Molecular Formula | C22H27N2O5P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 412.3ºC | |
Use of LY 311727LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme[1][2]. |
| Name | 3-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxypropylphosphonic acid |
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| Synonym | More Synonyms |
| Description | LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme[1][2]. |
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| Related Catalog | |
| Target |
sPLA2[1] |
| In Vitro | LY-311727 (0.1-10 μM) suppresses the contractile responses induced by human non-pancreatic secretory phospholipase A2 (hnps-PLA2), in a concentration related manner[1]. LY-311727 nearly abolishes the hnps-PLA2 responses at 1μM, while it failed to suppress porcine pancreatic PLA2 concentration response curves at the same concentration[1]. LY-311727 displays 1,500-fold selectivity when assayed against porcine pancreatic s-PLA2[1]. |
| In Vivo | LY-311727 (3-30 mg/kg; i.v.) dramatically suppresses the circulating enzyme activity in mice with Mt-sPLA2 transgenic the intravenous (i.v.) administration[2]. Animal Model: C57BL/6J mice, metallothionein promoter-human secretory PLA2 minigene (Mt-sPLA2) transgenic mice model[2] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Intravenous injection Result: Significantly and dose dependently suppressed the PLA2 activity in the serum. |
| References |
| Density | 1.32g/cm3 |
|---|---|
| Boiling Point | 758.2ºC at 760mmHg |
| Molecular Formula | C22H27N2O5P |
| Molecular Weight | 430.43400 |
| Flash Point | 412.3ºC |
| Exact Mass | 430.16600 |
| PSA | 125.58000 |
| LogP | 4.37610 |
| Vapour Pressure | 3.69E-24mmHg at 25°C |
| Index of Refraction | 1.619 |
| Storage condition | 2-8°C |
| RIDADR | NONH for all modes of transport |
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| (3-{[3-(2-Amino-2-Oxoethyl)-1-Benzyl-2-Ethyl-1h-Indol-5-Yl]oxy}propyl)phosphonic Acid |