BMY 29304
Modify Date: 2024-02-02 00:47:42
BMY 29304 structure
|
Common Name | BMY 29304 | ||
|---|---|---|---|---|
| CAS Number | 164802-68-0 | Molecular Weight | 2163.48000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C97H131N23O26S4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMY 29304Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research[1][2][3][4]. |
| Name | siamycin I |
|---|
| Description | Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research[1][2][3][4]. |
|---|---|
| Related Catalog | |
| Target |
HIV-1 HIV-2 |
| In Vitro | Siamycin I 浓度为 1 μM 轻微抑制 E. faecalis 的生长 (接种后 5 小时生长 80%)，浓度为 5 μM 时完全抑制生长 (接种后 12 小时无生长)[3]。 siamycin I (0-1 μM; 24 小时) 在 0.25 μM 浓度下轻微抑制生物膜形成，浓度高于 0.5 μM 时抑制作用显着[3]。 Siamycin I 抑制 C8166 细胞与慢性感染 HIV 的 CEM-SS 细胞之间的融合 (ED50=0.08 μM)，但对 Sendai 病毒诱导的融合或小鼠成肌细胞融合没有影响[4]。 |
| References |
| Molecular Formula | C97H131N23O26S4 |
|---|---|
| Molecular Weight | 2163.48000 |
| Exact Mass | 2161.85000 |
| PSA | 848.94000 |
| LogP | 2.16980 |