MLS000532223
MLS000532223 structure
|
Common Name | MLS000532223 | ||
|---|---|---|---|---|
| CAS Number | 16616-39-0 | Molecular Weight | 251.23700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H9NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MLS000532223MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity [1]. |
| Name | 1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity [1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 16-120 μM (Rho family GTPases)[1] |
| In Vitro | MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1]. MLS000532223 modulates Rho-family GTP-binding kinetics[1]. MLS000532223 is active in cell–based assays and inhibits EGF-stimulated Rac 1 activation[1]. MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1]. MLS000532223 (10 μM) modulates actin remodeling in mast cells[1]. MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1]. |
| References |
| Molecular Formula | C15H9NO3 |
|---|---|
| Molecular Weight | 251.23700 |
| Exact Mass | 251.05800 |
| PSA | 62.89000 |
| LogP | 3.35240 |
|
~89%
MLS000532223 CAS#:16616-39-0 |
| Literature: Shvartsberg, M. S.; Fedenok, L. G. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 9.2. p. 1906 - 1910 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , vol. 39, # 9 p. 2094 - 2098 |
|
~90%
MLS000532223 CAS#:16616-39-0 |
| Literature: Shen, Ying-Lin; Wu, Wen-Tao; Liu, Qiang; Wu, Guai-Li; Wu, Long-Min Journal of Chemical Research, 2006 , # 8 p. 545 - 546 |
|
~%
MLS000532223 CAS#:16616-39-0 |
| Literature: Zhou, Jun; Zhang, Guang-Liang; Zou, Jian-Ping; Zhang, Wei European Journal of Organic Chemistry, 2011 , # 19 p. 3412 - 3415 |
|
~%
MLS000532223 CAS#:16616-39-0 |
| Literature: Zhou, Jun; Zhang, Guang-Liang; Zou, Jian-Ping; Zhang, Wei European Journal of Organic Chemistry, 2011 , # 19 p. 3412 - 3415 |
|
~13%
MLS000532223 CAS#:16616-39-0
Detail
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| Literature: Zhang, Jing; Wang, Yongyong; Zhao, Xiaoli; Liu, Ye European Journal of Inorganic Chemistry, 2014 , # 6 p. 975 - 985 |
| m-Nitrobenzoylphenylacetylen |
| 1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one |
| 2-Propyn-1-one,1-(3-nitrophenyl)-3-phenyl |
| 1-Phenyl-3-(3-nitrophenyl)-1-propin-3-on |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: MLS000532223
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: MLS-000532223
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: MLS-000532223
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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