Metaxalone

Modify Date: 2024-01-02 20:38:24

Metaxalone Structure
Metaxalone structure
Common Name Metaxalone
CAS Number 1665-48-1 Molecular Weight 221.252
Density 1.1±0.1 g/cm3 Boiling Point 453.6±14.0 °C at 760 mmHg
Molecular Formula C12H15NO3 Melting Point 121-123ºC
MSDS Chinese USA Flash Point 228.2±20.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Metaxalone


Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.

 Names

Name Metaxalone
Synonym More Synonyms

 Metaxalone Biological Activity

Description Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Metaxalone

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 453.6±14.0 °C at 760 mmHg
Melting Point 121-123ºC
Molecular Formula C12H15NO3
Molecular Weight 221.252
Flash Point 228.2±20.1 °C
Exact Mass 221.105194
PSA 47.56000
LogP 2.42
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.525
Storage condition -20°C Freezer

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ3850000
CHEMICAL NAME :
2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
CAS REGISTRY NUMBER :
1665-48-1
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H15-N-O3
MOLECULAR WEIGHT :
221.28
WISWESSER LINE NOTATION :
T5MVOTJ D1OR C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
515 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1690 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,326,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR NONH for all modes of transport
RTECS RQ3850000

 Synthetic Route

~97%

Metaxalone Structure

Metaxalone

CAS#:1665-48-1

Literature: Dabur Pharma Ltd. Patent: US2007/185177 A1, 2007 ; Location in patent: Page/Page column 8 ;

~78%

Metaxalone Structure

Metaxalone

CAS#:1665-48-1

Literature: Yung Shin Pharma Ind. Co., Ltd. Patent: US6562980 B1, 2003 ;

~92%

Metaxalone Structure

Metaxalone

CAS#:1665-48-1

Literature: BOEHRINGER INGELHEIM CHEMICALS, INC. Patent: WO2008/6096 A1, 2008 ; Location in patent: Page/Page column 2-4 ;

~16%

Metaxalone Structure

Metaxalone

CAS#:1665-48-1

Literature: AUSPEX PHARMACEUTICALS, INC. Patent: US2009/270469 A1, 2009 ; Location in patent: Page/Page column 28 ;

~%

Metaxalone Structure

Metaxalone

CAS#:1665-48-1

Literature: Journal of Medicinal Chemistry, , vol. 38, # 20 p. 3983 - 3994

 Articles3

More Articles
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.

Clin. Ther. 26(9) , 1355-67, (2004)

Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support.The aim of this review was to discuss the etiology of low back pain an...

Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form.

Sci. Pharm. 80(2) , 353-66, (2012)

A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination o...

Metaxalone (Skelaxin)-related death.

J. Anal. Toxicol. 28(6) , 537-41, (2004)

The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatograp...

 Synonyms

5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Metaxalone
5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
Metaxolone
MFCD00867700
5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone
Skelaxin
EINECS 216-777-6