OPC-28326

Modify Date: 2024-01-02 22:59:24

OPC-28326 structure	Common Name	OPC-28326
	CAS Number	167626-17-7	Molecular Weight	421.575
	Density	1.1±0.1 g/cm3	Boiling Point	624.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	331.5±31.5 °C

Use of OPC-28326

OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

Name	OPC-28326
Synonym	More Synonyms

Description	OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
Target	Ki: 2040 nM (α2A adrenoceptor), 285 nM (α2B adrenoceptor), 55 nM (α2C adrenoceptor)[2]
In Vitro	OPC-28326 enhances endothelial tube formation and promotes microvessel growth. OPC-28326 induces phosphorylation of eNOS and Akt in HAECs in a dose dependent-manner, while it does not affect total amounts of eNOS and Akt[1]. OPC-28326 (1-100 μM) and yohimbine (10-1000 nM) causes a rightward shift in the concentration-response curve of clonidine[2].
In Vivo	OPC-28326 augments blood flow recovery in murine hindlimb ischemia. OPC-28326 significantly increases the number of histologically detectable capillaries in the ischemic leg. OPC-28326 has no beneficial effects on blood flow recovery in eNOS−/− mice[1]. OPC-28326 (3-30 mg/kg, i.v.) and yohimbine causes dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. OPC-28326 does not affect on the mydriasis in rats[2].
Animal Admin	Unilateral hindlimb ischemia is induced in 30- to 35-week-old male mice by resecting the right femoral and saphenous arteries. The mice are fed on regular chow (Ctrl), chow containing 0.02% (OPC(L)) or 0.05% (OPC(H)) OPC-28326, starting one week before the surgery (n = 10 for each group). Hindlimb blood perfusion is measured using a laser Doppler perfusion imager (LDPI) system. Excess hairs are removed from the limbs using depilatory cream before imaging, and mice are placed on a heating plate at 40°C. To avoid the influence of ambient light and temperature, the results are expressed as the ratio of perfusion in the right (ischemic) versus left (untreated) limb. The thigh muscles are harvested at 4 weeks and stained for CD31 (clone MEC13.1) to detect endothelial cells. Capillaries are identified by positive staining for CD31 and their morphology. Ten different fields from each tissue preparation are randomly selected and capillaries are counted. Capillary density is expressed as the number of capillaries per square millimeter.
References	[1]. Sumi M, et al. OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis. Biomed Pharmacother. 2007 May;61(4):209-15. Epub 2006 Dec 28. [2]. Orito K, et al. alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. Br J Pharmacol. 2001 Oct;134(4):763-70.

Density	1.1±0.1 g/cm3
Boiling Point	624.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₅N₃O₂
Molecular Weight	421.575
Flash Point	331.5±31.5 °C
Exact Mass	421.272919
LogP	3.59
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.590

Propanamide, N-[2,6-dimethyl-4-[[4-[methyl(2-phenylethyl)amino]-1-piperidinyl]carbonyl]phenyl]-

N-[2,6-Dimethyl-4-({4-[methyl(2-phenylethyl)amino]-1-piperidinyl}carbonyl)phenyl]propanamide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: OPC-28326
Price: Negotiable
Purity: 98.56%
Delivery: 10 Day
Contact: Huang
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OPC-28326

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