FzM1
Modify Date: 2024-01-02 18:43:16
FzM1 structure
|
Common Name | FzM1 | ||
|---|---|---|---|---|
| CAS Number | 1680196-54-6 | Molecular Weight | 360.429 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 518.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H16N2O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 267.2±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of FzM1A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism; induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes. |
| Name | FzM1 |
|---|---|
| Synonym | More Synonyms |
| Description | A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism; induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes. |
|---|---|
| References | References 1. Generoso SF, et al. Nat Chem Biol. 2015 Apr;11(4):280-6. 2. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087. View Related Products by Target Frizzled |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 518.3±50.0 °C at 760 mmHg |
| Molecular Formula | C21H16N2O2S |
| Molecular Weight | 360.429 |
| Flash Point | 267.2±30.1 °C |
| Exact Mass | 360.093262 |
| LogP | 5.29 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.779 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
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Pharmacological folding chaperones act as allosteric ligands of Frizzled4.
Nat. Chem. Biol. 11(4) , 280-6, (2015) Upon binding, ligands can chaperone their protein targets by preventing them from misfolding and aggregating. Thus, an organic molecule that works as folding chaperone for a protein might be its speci... |
| Urea, N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl- |
| FzM1 |
| 1-[3-Hydroxy-5-(2-thienyl)phenyl]-3-(2-naphthyl)urea |
| 1-(3-hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea |