1680196-54-6

1680196-54-6 structure

Name: FzM1
Chemical Name: FzM1
CAS Number: 1680196-54-6
Molecular Formula: C₂₁H₁₆N₂O₂S
Molecular Weight: 360.429
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2020-01-11 18:19:51
Modify Date: 2024-01-02 18:43:16
A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism; induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes.

Name	FzM1
Synonyms	Urea, N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl- FzM1 1-[3-Hydroxy-5-(2-thienyl)phenyl]-3-(2-naphthyl)urea 1-(3-hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea

Description	A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism; induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes.
References	References 1. Generoso SF, et al. Nat Chem Biol. 2015 Apr;11(4):280-6. 2. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087. View Related Products by Target Frizzled

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport