Kauran-16,17-diol (ent-Kauran-16beta,17-diol)

Modify Date: 2024-01-17 17:59:13

Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Structure
Kauran-16,17-diol (ent-Kauran-16beta,17-diol) structure
Common Name Kauran-16,17-diol (ent-Kauran-16beta,17-diol)
CAS Number 16836-31-0 Molecular Weight 306.48300
Density 1.09g/cm3 Boiling Point 422.3ºC at 760mmHg
Molecular Formula C20H34O2 Melting Point N/A
MSDS N/A Flash Point 186.8ºC

 Use of Kauran-16,17-diol (ent-Kauran-16beta,17-diol)


Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].

 Names

Name Kauran-16,17-diol
Synonym More Synonyms

  Biological Activity

Description Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
Related Catalog
In Vitro Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1].
References

[1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52.

[2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.

 Chemical & Physical Properties

Density 1.09g/cm3
Boiling Point 422.3ºC at 760mmHg
Molecular Formula C20H34O2
Molecular Weight 306.48300
Flash Point 186.8ºC
Exact Mass 306.25600
PSA 40.46000
LogP 4.14260
Vapour Pressure 6.7E-09mmHg at 25°C
Index of Refraction 1.55
Storage condition 2-8℃

 Synthetic Route

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Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Structure

Kauran-16,17-di...

CAS#:16836-31-0

Literature: Kitajima; Komori; Kawasaki Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 3912 - 3921

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Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Structure

Kauran-16,17-di...

CAS#:16836-31-0

Literature: Kitajima; Komori; Kawasaki Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 3912 - 3921

~%

Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Structure

Kauran-16,17-di...

CAS#:16836-31-0

Literature: Hanson,J.R. Journal of the Chemical Society, 1963 , p. 5061 - 5066

~%

Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Structure

Kauran-16,17-di...

CAS#:16836-31-0

Literature: Kitajima; Komori; Kawasaki Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 3912 - 3921

~%

Kauran-16,17-diol (ent-Kauran-16beta,17-diol) Structure

Kauran-16,17-di...

CAS#:16836-31-0

Literature: Hanson,J.R. Journal of the Chemical Society, 1963 , p. 5061 - 5066

 Synonyms

Ent-kauran-16,17-diol
Kaurane-16,17-diol
(5beta,9beta,10alpha,16beta)-Kaurane-16,17-Diol
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