Adrenocorticotropic Hormone Fragment 1-24 human

Modify Date: 2024-01-02 15:52:26

Adrenocorticotropic Hormone Fragment 1-24 human structure	Common Name	Adrenocorticotropic Hormone Fragment 1-24 human
	CAS Number	16960-16-0	Molecular Weight	2933.437
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₁S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Adrenocorticotropic Hormone Fragment 1-24 human

Tetracosactide (INN) is an analogue of adrenocorticotrophic hormone (ACTH), with the biological activity of stimulating production of corticosteroids in the adrenal cortex. Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro.

Name	Cosyntropin
Synonym	More Synonyms

Description	Tetracosactide (INN) is an analogue of adrenocorticotrophic hormone (ACTH), with the biological activity of stimulating production of corticosteroids in the adrenal cortex. Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Peptides

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₁S
Molecular Weight	2933.437
Exact Mass	2931.580566
PSA	1184.02000
LogP	-3.27
Index of Refraction	1.681
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GM7915000

CHEMICAL NAME :: alpha(sup 1-24)-Corticotropin

CAS REGISTRY NUMBER :: 16960-16-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C136-H210-N40-O31-S

MOLECULAR WEIGHT :: 2933.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 5 ug/kg

TOXIC EFFECTS :: Cardiac - change in rate Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 237,879,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4549 No. of Facilities: 24 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1071 (estimated) No. of Female Employees: 546 (estimated)

RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GM7915000

An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.

J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015)

Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

The relationship between vitamin D status and adrenal insufficiency in critically ill children.

J. Clin. Endocrinol. Metab. 98(5) , E877-81, (2013)

Recent studies in critically ill populations have suggested both adrenal insufficiency (AI) and vitamin D deficiency to be associated with worse clinical outcome. There are multiple mechanisms through...

Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH₁₋₂₄ stimulation in the assessment of pituitary patients.

J. Clin. Endocrinol. Metab. 98(5) , 1883-90, (2013)

Measurement of plasma cortisol by immunoassay after ACTH₁₋₂₄ stimulation is used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Liquid chromatography-tandem mass spectrometry (LCMS) has grea...

Cortrosyn

y-29-(4-hydroxybenzyl)-26-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-8-(1H-indol-3-ylmethyl)-23-[2-(methylsulfanyl)ethyl]-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritria

L-proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-

MFCD00167476

L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-v alyl-L-lysyl-L-valyl-L-tyrosyl-

cosyntropin

α1-24-Corticotropin

L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline

EINECS 241-031-1

Adrenocorticotropic Hormone Fragment 1-24 human, rat

Tetracosactide

L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy

Porcine ACTH (1-24)

Tetracosactide Acetate