ML00253764 hydrochloride
Modify Date: 2024-01-23 10:03:21
ML00253764 hydrochloride structure
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Common Name | ML00253764 hydrochloride | ||
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| CAS Number | 1706524-94-8 | Molecular Weight | 413.71 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19BrClFN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML00253764 hydrochlorideML-00253764 is a nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 µM and 0.103 µM, respectively. Brain penetrant[1]. |
| Name | ML-00253764 hydrochloride |
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| Description | ML-00253764 is a nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 µM and 0.103 µM, respectively. Brain penetrant[1]. |
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| Related Catalog | |
| In Vitro | ML-00253764 displaces NDP-α-MSH binding with a mean IC50 of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively[1]. ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes[1]. |
| In Vivo | ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice[1]. ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 ml/kg[1]. Animal Model: CT-26 tumor bearing BALB/c mice[1] Dosage: 3, 10, or 30 mg/kg Administration: Subcutaneous injection; 3, 10, or 30 mg/kg; once daily Result: Reduced tumor-induced weight loss in a mouse model. |
| References |
| Molecular Formula | C18H19BrClFN2O |
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| Molecular Weight | 413.71 |