ML00253764

Modify Date: 2024-01-08 02:34:31

ML00253764 Structure
ML00253764 structure
Common Name ML00253764
CAS Number 681847-92-7 Molecular Weight 413.712
Density N/A Boiling Point N/A
Molecular Formula C18H19BrClFN2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML00253764


ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1].

 Names

Name 2-{2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole hydrochloride (1:1)
Synonym More Synonyms

 ML00253764 Biological Activity

Description ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1].
Related Catalog
In Vitro ML00253764(0.001-50 μM, 24 h or 72 h)对人胶质母细胞瘤细胞增殖具有显著的时间和浓度依赖性抑制活性,其中作用于 U-118 细胞的 IC50 值为 6.56 μM,可以诱导U-87细胞凋亡,且在这两种细胞系中均表现出显著的 ERK1/2 磷酸化抑制作用[1]。
In Vivo ML00253764(30 mg/kg, s.c., daily, 34 days) 可抑制感染 U-87 细胞的 CD nu/nu 雄性小鼠肿瘤生长[1]。
References

[1]. Francesca Vaglini, et al. Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo. Mol Neurobiol. 2018 Jun;55(6):4984-4997.   

 Chemical & Physical Properties

Molecular Formula C18H19BrClFN2O
Molecular Weight 413.712
Exact Mass 412.035309

 Synonyms

1H-Imidazole, 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-, hydrochloride (1:1)
2-{2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole hydrochloride (1:1)
MFCD28133377
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Price: ¥1650/10 mM * 1 mL in DMSO

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