12-epi-TadalafilTadalafil

Modify Date: 2024-01-02 22:20:08

12-epi-TadalafilTadalafil Structure
12-epi-TadalafilTadalafil structure
Common Name 12-epi-TadalafilTadalafil
CAS Number 171596-27-3 Molecular Weight 389.40
Density 1.51±0.1 g/cm3 (20 ºC 760 Torr) Boiling Point N/A
Molecular Formula C22H19N3O4 Melting Point 295-296 ºC
MSDS N/A Flash Point N/A

 Use of 12-epi-TadalafilTadalafil


cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].

 Names

Name (6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Synonym More Synonyms

 12-epi-TadalafilTadalafil Biological Activity

Description cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].
Related Catalog
Target

PDE5:0.09 μM (IC50)

In Vitro cis-Tadalafil (Compound 12b) 抑制 PDE5,IC50 为 0.09 μM[1]。
References

[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42.  

 Chemical & Physical Properties

Density 1.51±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point 295-296 ºC
Molecular Formula C22H19N3O4
Molecular Weight 389.40
Exact Mass 389.13800
PSA 74.87000
LogP 2.08710
Water Solubility Insuluble (8.6E-3 g/L) (25 ºC)

 Synonyms

UNII-E319TQ0B6R
cis-ent-Tadalafil
PYR403
12-epi-TadalafilTadalafil
Tadalafil Impurity 13
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