(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid

Modify Date: 2024-01-04 17:03:09

(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid structure	Common Name	(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid
	CAS Number	173075-45-1	Molecular Weight	468.668
	Density	1.1±0.1 g/cm3	Boiling Point	602.1±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	332.0±28.0 °C

Use of (24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

Name	ganoderic acid dm
Synonym	More Synonyms

Description	Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1]. Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2]. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3]. Cell Viability Assay[1] Cell Line: MCF-7 and MDA-MB-231 cells. Concentration: 0-100 μM. Incubation Time: 48 h. Result: Decreased the cell viability in breast cancer cells. Cell Viability Assay[2] Cell Line: RAW-D cells. Concentration: 0-100 μg/mL. Incubation Time: 0-100 μg/mL. Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.
References	[1]. Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83(2):408-14. [2]. Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602(1):1-7. [3]. Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.

Density	1.1±0.1 g/cm3
Boiling Point	602.1±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₄O₄
Molecular Weight	468.668
Flash Point	332.0±28.0 °C
Exact Mass	468.323975
PSA	71.44000
LogP	6.90
Vapour Pressure	0.0±3.7 mmHg at 25°C
Index of Refraction	1.547