BGC 20-761
Modify Date: 2024-01-09 08:58:40
BGC 20-761 structure
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Common Name | BGC 20-761 | ||
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| CAS Number | 17375-63-2 | Molecular Weight | 294.39100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H22N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BGC 20-761BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1]. |
| Name | 2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine |
|---|---|
| Synonym | More Synonyms |
| Description | BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1]. |
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| Related Catalog | |
| Target |
Human 5-HT6 Receptor:20 nM (Ki) Human 5-HT2A Receptor:69 nM (Ki) Human D2 Receptor:140 nM (Ki) |
| In Vitro | BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat Ki values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM)[1]. |
| In Vivo | BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.)[1]. Animal Model: Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats[1] Dosage: 2.5 mg/kg, 5 mg/kg and 10 mg/kg Administration: Administered (i.p.) immediately after the training session for the social recognition test Result: Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition. |
| References |
| Molecular Formula | C19H22N2O |
|---|---|
| Molecular Weight | 294.39100 |
| Exact Mass | 294.17300 |
| PSA | 28.26000 |
| LogP | 3.94760 |
| 3-(2-Dimethylamino-aethyl)-indol-5-ol,Hydrogenoxalat |
| 3-(2-dimethylamino-ethyl)-indol-5-ol,hydrogenoxalate |
| Bufotenin Oxalate |
| bufotenin monooxalate |
| [2-(5-methoxy-2-phenyl-indol-3-yl)-ethyl]-dimethyl-amine |
| 3-(2-(Dimethylamino)ethyl)indol-5-ol oxalate |
| Indol-5-ol,oxalate |
| N,N-dimethyl-2-(5-hydroxy-1H-indol-3-yl)ethylamine oxalate |
| Bufotenin-bioxalat |
| N,N-dimethyl-2-(5-methoxy-2-phenylindol-3-yl)ethylamine |
| bufotenine monooxalate |