XR 5118
Modify Date: 2024-10-12 11:55:46
XR 5118 structure
|
Common Name | XR 5118 | ||
|---|---|---|---|---|
| CAS Number | 174766-49-5 | Molecular Weight | 435.985 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H22ClN3O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XR 5118XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo. Thrombosis Discontinued |
| Name | XR 5118 |
|---|
| Description | XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo. Thrombosis Discontinued |
|---|---|
| References | References 1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21. 2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32. 3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1) Thrombosis |
| Molecular Formula | C20H22ClN3O2S2 |
|---|---|
| Molecular Weight | 435.985 |