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89459-25-6

89459-25-6 structure
89459-25-6 structure
  • Name: XR-5000
  • Chemical Name: N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
  • CAS Number: 89459-25-6
  • Molecular Formula: C18H19N3O
  • Molecular Weight: 293.36300
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
  • Create Date: 2016-09-01 03:13:39
  • Modify Date: 2024-01-14 11:41:29
  • DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].

Name N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
Synonyms Acridine carboxamide
N-(2-(Dimethylamino)ethyl)-4-acridinecarboxamide
N-(2-(Dimehtylamino)ehtyl)acridine-4-carboxamide
Daca
4-Acridinecarboxamide,N-(2-(dimethylamino)ethyl)
N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide
Description DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].
Related Catalog
References

[1]. Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000;60(6):817-821.  

Density 1.182g/cm3
Boiling Point 544.1ºC at 760 mmHg
Molecular Formula C18H19N3O
Molecular Weight 293.36300
Flash Point 282.9ºC
Exact Mass 293.15300
PSA 48.72000
LogP 3.25420
Index of Refraction 1.657
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR7622610
CHEMICAL NAME :
4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-
CAS REGISTRY NUMBER :
89459-25-6
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H19-N3-O
MOLECULAR WEIGHT :
293.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
44597 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
150 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,35,1992

~%

89459-25-6 structure

89459-25-6

Literature: Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929

~62%

89459-25-6 structure

89459-25-6

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702 Title/Abstract Full Text View citing articles Show Details Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929

~%

89459-25-6 structure

89459-25-6

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702

~%

89459-25-6 structure

89459-25-6

Literature: Atwell, Graham J.; Rewcastle, Gordon W.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 664 - 669