DC Chemicals Limited
China
Product Name: XR-5000
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
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Purity: 98.0%
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89459-25-6

89459-25-6 structure

Name: XR-5000
Chemical Name: N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
CAS Number: 89459-25-6
Molecular Formula: C₁₈H₁₉N₃O
Molecular Weight: 293.36300
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2016-09-01 03:13:39
Modify Date: 2024-01-14 11:41:29
DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].

Name	N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
Synonyms	Acridine carboxamide N-(2-(Dimethylamino)ethyl)-4-acridinecarboxamide N-(2-(Dimehtylamino)ehtyl)acridine-4-carboxamide Daca 4-Acridinecarboxamide,N-(2-(dimethylamino)ethyl) N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide

Description	DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000;60(6):817-821.

Density	1.182g/cm3
Boiling Point	544.1ºC at 760 mmHg
Molecular Formula	C₁₈H₁₉N₃O
Molecular Weight	293.36300
Flash Point	282.9ºC
Exact Mass	293.15300
PSA	48.72000
LogP	3.25420
Index of Refraction	1.657
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7622610

CHEMICAL NAME :: 4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-

CAS REGISTRY NUMBER :: 89459-25-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H19-N3-O

MOLECULAR WEIGHT :: 293.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44597 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 150 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,35,1992

188054-38-8

89459-25-6

Literature: Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929

108-00-9

188054-45-7

~62%

89459-25-6

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702 Title/Abstract Full Text View citing articles Show Details Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929

100038-81-1

89459-25-6

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702

24782-64-7

89459-25-6

Literature: Atwell, Graham J.; Rewcastle, Gordon W.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 664 - 669

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