Name | N-[2-(dimethylamino)ethyl]acridine-4-carboxamide |
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Synonyms |
Acridine carboxamide
N-(2-(Dimethylamino)ethyl)-4-acridinecarboxamide N-(2-(Dimehtylamino)ehtyl)acridine-4-carboxamide Daca 4-Acridinecarboxamide,N-(2-(dimethylamino)ethyl) N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide |
Description | DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1]. |
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Related Catalog | |
References |
Density | 1.182g/cm3 |
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Boiling Point | 544.1ºC at 760 mmHg |
Molecular Formula | C18H19N3O |
Molecular Weight | 293.36300 |
Flash Point | 282.9ºC |
Exact Mass | 293.15300 |
PSA | 48.72000 |
LogP | 3.25420 |
Index of Refraction | 1.657 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
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~% 89459-25-6 |
Literature: Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929 |
~62% 89459-25-6 |
Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702 Title/Abstract Full Text View citing articles Show Details Spicer, Julie A.; Gamage, Swarna A.; Atwell, Graham J.; Finlay, Graeme J.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1919 - 1929 |
~% 89459-25-6 |
Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 699 - 702 |
~% 89459-25-6 |
Literature: Atwell, Graham J.; Rewcastle, Gordon W.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 664 - 669 |