Dropropizine

Modify Date: 2024-01-02 13:29:58

Dropropizine structure	Common Name	Dropropizine
	CAS Number	17692-31-8	Molecular Weight	236.310
	Density	1.2±0.1 g/cm3	Boiling Point	412.7±34.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₂₀N₂O₂	Melting Point	105-108ºC
	MSDS	Chinese USA	Flash Point	220.9±24.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Dropropizine

Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.

Name	3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Synonym	More Synonyms

Description	Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology

Density	1.2±0.1 g/cm3
Boiling Point	412.7±34.0 °C at 760 mmHg
Melting Point	105-108ºC
Molecular Formula	C₁₃H₂₀N₂O₂
Molecular Weight	236.310
Flash Point	220.9±24.3 °C
Exact Mass	236.152481
PSA	46.94000
LogP	0.46
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.577

Dropropizine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1074800

CHEMICAL NAME :: 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 17692-31-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H20-N2-O2

MOLECULAR WEIGHT :: 236.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TZ1074800
HS Code	2933599090

(R,S)-3-(4-phen...

CAS#:142730-57-2

N/A

CAS#:142730-59-4

N/A

CAS#:142730-58-3

Dropropizine

CAS#:17692-31-8

Literature: Tetrahedron Letters, , vol. 33, # 22 p. 3231 - 3234

Precursor 1
CAS#:142730-57-2 (R,S)-3-(4-phen...
DownStream 0

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.

J. Int. Med. Res. 23(3) , 175-83, (1995)

The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e...

Efficacy of levodropropizine in pediatric cough.

Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012)

Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir...

Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Ther. Drug Monit. 26(4) , 441-9, (2004)

Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma...

Dropropizine

1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-

Tussilex

1-(2,3-Dihydroxypropyl)-4-phenylpiperazine

(+-)-Dropropizine

Ribex

EINECS 241-683-7

Larylin

Ditustat

1-Phenyl-4-(2,3-dihydroxypropyl)piperazine

1-Phenyl-4-(2,3-dihydroxypropyl)diethylenediamine

Dipropizine

MFCD00079124

3-(4-phenylpiperazin-1-yl)propane-1,2-diol

Dopropizin

Catabex

levodropropizine

3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

Katril

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dropropizine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dropropizine
Price: ￥588.0/25g ￥678.0/100g ￥88.0/5g
Purity: 97.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Dropropizine
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dropropizine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $66/10mM*1mLinDMSO

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Dropropizine

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