3,4,5-Trihydroxycinnamic acid decyl ester

Modify Date: 2024-01-10 13:37:16

3,4,5-Trihydroxycinnamic acid decyl ester Structure
3,4,5-Trihydroxycinnamic acid decyl ester structure
Common Name 3,4,5-Trihydroxycinnamic acid decyl ester
CAS Number 1770778-45-4 Molecular Weight 336.42
Density N/A Boiling Point N/A
Molecular Formula C19H28O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 3,4,5-Trihydroxycinnamic acid decyl ester


3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM[1].

 Names

Name 3,4,5-Trihydroxycinnamic acid decyl ester

  Biological Activity

Description 3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM[1].
Related Catalog
Target

EC50: 0.9 μM (pancreatic lipase)[1]

In Vitro 3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro[1]. 3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC50 value being approximately 0.9 μM[1]. 3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation[1].
In Vivo 3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally[1]. Animal Model: 6 weeks old Male ddY mice[1] Dosage: 30 mg/kg, 150 mg/kg Administration: Oral administration Result: Reduced plasma TG in a dose-dependent manner.
References

[1]. Masahiko Imai ,et al. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorg Med Chem. 2015 Jul 1;23(13):3788-95.

 Chemical & Physical Properties

Molecular Formula C19H28O5
Molecular Weight 336.42

 Safety Information

Hazard Codes Xi
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