MRT67307 dihydrochloride

Modify Date: 2024-01-21 12:02:17

MRT67307 dihydrochloride Structure
MRT67307 dihydrochloride structure
Common Name MRT67307 dihydrochloride
CAS Number 1781882-89-0 Molecular Weight 537.52
Density N/A Boiling Point N/A
Molecular Formula C26H38Cl2N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MRT67307 dihydrochloride


MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].

 Names

Name MRT67307 dihydrochloride

 MRT67307 dihydrochloride Biological Activity

Description MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].
Related Catalog
References

[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.  

[2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.  

 Chemical & Physical Properties

Molecular Formula C26H38Cl2N6O2
Molecular Weight 537.52